منابع مشابه
TRP Is Cracked but Is CRAC TRP?
fly's compound eye. Unlike many genetically identified proteins in this system, which are enzymes in the phos-Mayo Foundation Rochester, Minnesota 55905 phatidylinositol pathway, TRP and TRPL were originally presumed to be ion channels based on their putative It takes only one close look at a housefly to tell you six transmembrane-spanning topology and the phenotype of the associated trp mutant...
متن کاملSorting out MIC, TRP, and CRAC Ion Channels
A horde of cation-nonselective ion channel clans populate cell membranes. Their number is further augmented by removing extracellular calcium ([Ca 2 ] o ), turning well-behaved Ca 2 -selective channels into less discriminating sieves (Kostyuk and Krishtal, 1977; Almers and McCleskey, 1984). The Ca 2 ion stems the flood of ions moving through many cation channels by lodging in their throats, obs...
متن کاملNompC TRP Channel Is Essential for Drosophila Sound Receptor Function
The idea that the NompC TRPN1 channel is the Drosophila transducer for hearing has been challenged by remnant sound-evoked nerve potentials in nompC nulls. We now report that NompC is essential for the function of Drosophila sound receptors and that the remnant nerve potentials of nompC mutants are contributed by gravity/wind receptor cells. Ablating the sound receptors reduces the amplitude an...
متن کاملC. elegans TRP Family Protein TRP-4 Is a Pore-Forming Subunit of a Native Mechanotransduction Channel
Mechanotransduction channels mediate several common sensory modalities such as hearing, touch, and proprioception; however, very little is known about the molecular identities of these channels. Many TRP family channels have been implicated in mechanosensation, but none have been demonstrated to form a mechanotransduction channel, raising the question of whether TRP proteins simply play indirec...
متن کاملThe innate immunity role of cathepsin-D is linked to Trp-491 and Trp-492 residues of listeriolysin O.
Listeriolysin O (LLO) is a thiol-activated cytolysin secreted by Listeria monocytogenes. LLO and phosphatidylinositol phospholipase C are two essential virulence factors, which this bacterium needs to escape from the phagosomal compartment to the cytoplasm. Cathepsin-D specifically cleaves LLO, between the Trp-491 (tryptophan amino acid in three letter nomenclature) and Trp-492 residues of the ...
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ژورنال
عنوان ژورنال: Neuron
سال: 1996
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80132-4